Consider the following nothing greater than a taste of this huge medical system. The antidepressant M039 ( H. perforatum ) might block this pathway and additional disturb the GNAQ, GNAI and GNAS within the SSRI pathway to activate cAMP responsive factor binding protein 1 . All this means that some herbs may be potential therapeutic instruments for dealing with despair via indirect actions on this pathway. Distribution of target proteins of herbs on the compressed ‘depression pathway’. Arrows point out activation, T-arrows indicated inhibition and segments point out actions that may both be activatory or inhibitory on the specific targets.