The study protocol was approved by the Institutional Animal Care and Use Committee. Analysis of the 196,276 sequences of S protein variants obtained from the GISAID database on November 15, 2020 revealed that the S protein has already mutated on 1,141 websites of the 1,273 amino acid sequences (i.e., ∼90% of the S protein has been mutated) (Fig. 5). However, glycosylation is cell-specific and the position of glycosylation in S protein throughout viral infection and interaction with different host proteins in airway epithelial cells isn’t nicely understood and might be a subject for additional investigation. Nevertheless, regardless of the broad scope of mutation in the S protein, it seems that most variants still interact with ACE2, suggesting that the RBD area might have little change in conformation and ACE2 might function a decoy to dam the entry of the virus. Patients or physicians mustn’t interact in natural usage for complicated conditions with out information. Similarly, each water and oxygen can kill in extreme quantities, so quantity is commonly an essential consideration (2-4).