Second, we focus on the exploration of the energetic elements and targets by carrying out complicated structure-, omics- and network-based systematic investigations. Third, particular informatics strategies are developed to deduce drug–disease connections, with function to grasp how medication work on the precise targets and pathways. The use of natural medicine is not restricted to developing countries. Over the years, there has been an escalating interest in the utilization of natural medicine worldwide. This has greatly expanded the demand for plant merchandise, since natural medication has a bonus of being cheap with minimal unwanted effects in comparison with synthetic medicines. The progress of the natural drug market has attracted pharmaceutical companies which in flip have driven scientific validation and clinical studies on natural medicines.